Communication orale de Benjamin Buaud, Responsable projet Nutrition ITERG, 11th Biennial ISSFAL Congress, 28 juin - 2 juillet 2014, Stockholm
A. Létondor (1,2,3), B. Buaud (3), Carole Vaysse (3), L. Fonseca (3), Coralie Herrouin (3), Benjamin Servat (1,2,3), S. Layé (1,2), V. Pallet (1,2), S. Alfos (1,2)
1) Univ . Bordeaux, Nutrition et Neurobiologie Intégrée, UMR 1286, 33000 Bordeaux, France.
2) INRA, Nutrition et Neurobiologie Intégrée, UMR 1286, 33000 Bordeaux, France.
3) ITERG, Institut des Corps Gras, 33600 Pessac, France1
Présentation de résultats obtenus dans le cadre des travaux de l’UMT ACTIA ALICE, menés en collaboration avec le Laboratoire de Nutrition et Neurobiologie Intégrée NutriNeurO – UMR INRA 1286 – Université de Bordeaux
Aging is associated with changes in brain n-3 long-chain polyunsaturated fatty acid (n-3 LC-PUFA) levels, with primarily DHA playing a critical role in maintaining brain functions. However, limited data have shown the effects of aging and n-3 LC-PUFA dietary supplementation during aging on both blood and brain fatty acid compositions. In the present study, we assessed the blood and brain fatty acid contents during aging (13-month-old aged rats vs 3-week-old adult rats) and after n-3 LC-PUFA dietary supplementation in aged rats. In the blood, aging is associated to an increase in plasma DHA content whereas the DHA content remains stable in red blood cell (RBC) membranes. In the brain, aging is associated to a decrease in DHA content that was both region-specific and phospholipid class-specific, affecting mainly the striatum and more precisely the phosphatidylcholine. In n-3 LC-PUFA supplemented aged rats, the DHA contents were increased both in the blood and in the brain, to reach a brain DHA level close to, or higher than that measured in adult rats. As for aging, this repletion was region-specific and phospholipid class-specific. Furthermore, we highlighted a positive relationship between the DHA levels in RBC phosphatidylethanolamine (PE) and those in the hippocampus and prefrontal cortex in n-3 LC-PUFA supplemented aged rats. Within the framework of the formulation of a preventive nutrition to delay brain aging, these results (i) highlight the interest of n-3 LC-PUFA dietary supplementation during aging, and (ii) suggest the possibility of using the DHA content in RBC PE as a reliable biomarker of the DHA status in specific brain regions.