Influence du type de lipides en tant que vecteurs des oméga-3

Vectorisation, AGPI, Omega 3, Biodisponibilité, Lipides, Nutrition, Santé

Nouvelle publication de l’équipe Nutrition Santé & Biochimie des lipides, parue dans la revue « British Journal of Nutrition » 2019 – « In vitro lipolysis and lymphatic absorption of n-3 long-chain polyunsaturated fatty acids in the rat: influence of the molecular lipid species as carrier ».

Auteurs : A. Sehl, L. Couëdelo, I. Chamekh-Coelho, C. Vaysse, M. Cansell




The aim of this work was to study the bioavailability of fatty acids, focusing on n-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFA), carried by different molecular lipid species, i.e. phospholipids (PL) or triglycerides (TG), with three formulations based on fish oils or marine PL, providing a similar n-3 LC-PUFA amount. The digestive lipolysis was first assessed using an in vitro enzymatic model. Then, intestinal absorption and enterocyte metabolism were investigated in vivo, on male Wistar rats through lymph lipid analysis. The in vitro results showed that the release of n-3 LC-PUFA from lipolysis was increased by 48% when fatty acids were provided as PL rather than TG. The in vivo results demonstrated that eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) from both TG and PL were similarly absorbed and incorporated into lymph lipids. However, DHA was mainly distributed at the sn-1/3 positions of lymph TG when provided as marine PL, whereas it was equally distributed at the three positions with marine TG. On the whole, even if the molecular lipid species of n-3 LC-PUFA did not greatly modify the in vivo digestion and absorption steps, it modulated the rearrangement of DHA on the glyceride positions of the lymph TG, which may further impact the DHA metabolic fate and tissue accretion. Consequently, this study has provided data which may be used to formulate lipid diets rich in DHA in the context of an insufficient consumption of n-3 PUFA in Western countries.




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