La digestion des isomères de diacylglycérol par les lipases gastriques et pancréatiques et son impact …

La digestion des isomères de diacylglycérol par les lipases gastriques et pancréatiques et son impact sur les voies métaboliques de re-synthèse des TAG dans les entérocytes

Nouvelle publication parue dans la revue Biochimie, 15 janvier 2022

Résumé

The specific activities of gastric and pancreatic lipases were measured using triacylglycerols (TAG) from rapeseed oil, purified 1,3-sn-DAG and 1,2(2,3)-sn-DAG produced from this oil, as well as a rapeseed oil enriched with 40% w/w DAG (DAGOIL). Gastric lipase was more active on 1,3-sn-DAG than on 1,2(2,3)-sn-DAG and TAG, whereas pancreatic lipase displayed a reverse selectivity with a higher activity on TAG than on DAG taken as initial substrates. However, in both cases, the highest activities were displayed on DAGOIL. These findings show that DAG mixed with TAG, such as in the course of digestion, is a better substrate for lipases than TAG. The same rapeseed oil acylglycerols were used to investigate intestinal fat absorption in rats with mesenteric lymph duct cannulation.

Jean-ClaudeBakala N’Goma (a), Leslie Couëdelo (b), Carole Vaysse (b), Marion Letisse (c), Véronique Pierre (c), Alain Géloen (c), Marie-Caroline Michalski (c), Michel Lagarde (c), Jean-David Leao (b), Frédéric Carrière (a)

a Aix Marseille Univ, CNRS, UMR7281 Bioénergétique et Ingénierie des Protéines, 31 Chemin Joseph Aiguier, 13009, Marseille, France

b ITERG, Equipe Nutrition, Santé et Biochimie des Lipides, F-33610, Canejan, France

c Univ-Lyon, CarMeN laboratory, INRAE UMR1397, INSERM U1060, INSA-Lyon, Université Claude Bernard Lyon 1, F-69621, Villeurbanne, France

Accès en ligne : https://www.sciencedirect.com/science/article/abs/pii/S0300908422000128#!